Abstract

This research is related to a drug delivery system to accelerate wound healing in patients with diabetes mellitus using bioactive compounds from red betel leaf (Piper crocatum Ruiz and Pav) made in Nano-emulcream form. Bioactive natural ingredients made with nanoparticle technology have the advantages of more controlled and easily targeted delivery, on-target delivery and easy absorption, resulting in accelerated diabetic wound healing due to the flavonoid and tannin content. The developed nanoparticle system is expected to shorten the healing time of diabetic wounds. This study observed the diabetic wound healing process using Red Betel Leaf Extract Nano-Emulcream (Piper crocatum Ruiz and Pav) in experimental animals. This study used a true experimental laboratory study with a post-test only control group design. The research stages included the preparation of red betel leaf extract, the preparation of red betel leaf extract nano-emulcream, the preparation of experimental animals, the induction of diabetes in the experimental animals, the creation of traumatic ulcers in the experimental animals, the application of treatment, the observation of wound length, and the data analysis. Overall, this study demonstrates that the synthesized Nano-emulcream significantly improve the wound healing rate in diabetic rat models. The results of this study showed a significant difference in the use of Red Betel Leaf Extract Nano-Emulcream on days 2 and 7 with significance values ​​of 0.001 and 0.001, respectively (p-value <0.05). highlighted by the 10% Red Betel Leaf Extract Nano-Emulcream (Piper crocatum Ruiz and Pav) group which achieved the lowest wound length on day 7 compared to the control group.

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