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Biotechnology

Evaluating the synergistic antibacterial and anti-inflammatory effects of Kapok banana peel (Musa acuminata balbisiana colla) and Bay leaf (Syzygium polyanthum) extract gel formulation on wound healing: -

Nur An Nuha Muniroh Department of Medical Laboratory Technology, Faculty of Health Science, Universitas Muhammadiyah Purwokerto, Purwokerto, Indonesia, Indonesia Correspondence nurannuha2002@gmail.com
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Winda Rahma Cahyaningrum Department of Medical Laboratory Technology, Faculty of Health Science, Universitas Muhammadiyah Purwokerto, Purwokerto, Indonesia, Indonesia Correspondence windarahma17@gmail.com
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Deliza Dhiakhalda Sarinastiti Department of Medical Laboratory Technology, Faculty of Health Science, Universitas Muhammadiyah Purwokerto, Purwokerto, Indonesia, Indonesia Correspondence dlzdhiakhalda2305@gmail.com
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Respatiningtyas Amadea Danfi Putranti Department of Medical Laboratory Technology, Faculty of Health Science, Universitas Muhammadiyah Purwokerto, Purwokerto, Indonesia, Indonesia Correspondence respatiningtyasa@gmail.com
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Noha Hanifa Department of Medical Laboratory Technology, Faculty of Health Science, Universitas Muhammadiyah Purwokerto, Purwokerto, Indonesia, Indonesia Correspondence nohahanifa2018@gmail.com
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Kurnia Ritma Dhanti Department of Medical Laboratory Technology, Faculty of Health Science, Universitas Muhammadiyah Purwokerto, Purwokerto, Indonesia, Indonesia Correspondence krdhanti08@gmail.com
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Dita Pratiwi Kusuma Wardani Department of Medical Laboratory Technology, Faculty of Health Science, Universitas Muhammadiyah Purwokerto, Purwokerto, Indonesia, Indonesia Correspondence dita.tiwhie@gmail.com
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Arif Mulyanto Department of Medical Laboratory Technology, Faculty of Health Science, Universitas Muhammadiyah Purwokerto, Purwokerto, Indonesia, Indonesia Correspondence arifmulyanto02@gmail.com
Pages 60-72
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Abstract

The body's natural healing mechanisms rely significantly on substances that enhance tissue regeneration. Rapid growth of new skin cells can considerably accelerate wound healing. This study investigates the effectiveness of gel formulations derived from Saba banana peel (Musa acuminata balbisiana Colla) and bay leaf (Syzygium polyanthum) extracts as anti-inflammatory and antiseptic agents. Utilizing a true-experimental posttest-only control group design, we evaluated three different gel formulations: F1 (25% banana peel extract : 75% bay leaf extract), F2 (50% banana peel extract : 50% bay leaf extract), and F3 (75% banana peel extract : 25% bay leaf extract). Twenty white rats (Rattus norvegicus) were divided into five groups, each subjected to standardized incision wounds. Treatments were administered three times daily over a seven-day observation period, with wound healing assessed by measuring incision length. Formulation F1 demonstrated notable antibacterial efficacy against Staphylococcus aureus. Conversely, formulation F3 (75% banana peel : 25% bay leaf) exhibited superior wound healing performance, achieving an average healing rate of 42.97%, surpassing the positive control group. These findings indicate that gels containing extracts of Saba banana peel and bay leaf possess significant antibacterial activity against S. aureus and effectively enhance wound healing in animal models.

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How to Cite This

Muniroh, N. A. N., Cahyaningrum, W. R., Sarinastiti, D. D., Putranti, R. A. D., Hanifa, N., Dhanti, K. R., … Mulyanto, A. (2025). Evaluating the synergistic antibacterial and anti-inflammatory effects of Kapok banana peel (Musa acuminata balbisiana colla) and Bay leaf (Syzygium polyanthum) extract gel formulation on wound healing: -. Jurnal Teknologi Laboratorium, 14(1), 60–72. https://doi.org/10.29238/teknolabjournal.v14i1.483

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