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Histology

Bidara Leaf Extract (Ziziphus mauritiana L.): A Natural Approach to Enhancing Pancreatic Function and Lowering Blood Sugar in Male Wistar Rats

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Pages 44-52

Abstract

Diabetes mellitus is a metabolic disorder characterized by insufficient insulin production, leading to elevated blood glucose levels. When pancreatic beta cells produce inadequate insulin to compensate for increased insulin resistance, chronic hyperglycaemia ensues. This study investigates the effect of Bidara leaf extract (Ziziphus mauritiana) on the pancreatic function of male Wistar rats and its efficacy in reducing blood sugar levels. The experimental design was a post-test only controlled group study. Six groups were included: a control group receiving 1% Na CMC and five treatment groups receiving Bidara leaf ethanol extract at doses of 50 mg/kg, 100 mg/kg, 300 mg/kg, and 500 mg/kg, with each group consisting of four rats. Data analysis involved normality tests, homogeneity tests, and ANOVA. Results indicated that the p-value for each group was less than 0.05. Specifically, the 50 mg/kg dose of Bidara leaf extract significantly reduced blood sugar levels (p = 0.02). The 100 mg/kg dose showed a p-value of 0.14, indicating effectiveness in lowering blood sugar levels, though less pronounced. Similarly, the 300 mg/kg dose (p = 0.16) and the 500 mg/kg dose (p = 0.04) demonstrated significant hypoglycaemic effects. In conclusion, Bidara leaf extract has a dose-dependent effect on lowering blood sugar levels in male Wistar rats, with significant results observed at varying concentrations. Further research is recommended to explore the mechanisms involved and potential therapeutic applications in humans.

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How to Cite This

Nasution, M., Nasution, A. N., & Mutia, M. S. (2024). Bidara Leaf Extract (Ziziphus mauritiana L.): A Natural Approach to Enhancing Pancreatic Function and Lowering Blood Sugar in Male Wistar Rats. Jurnal Teknologi Laboratorium, 13(1), 44–52. https://doi.org/10.29238/teknolabjournal.v13i1.476

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