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Case-Study

The laboratory examination results: platelet, creatinine, and urea as predictors of mortality in Leptospirosis patients

Syahilla Efriana Program Study of Magister Epidemiology, Post Graduate School, Universitas Diponegoro, Semarang, Indonesia, Indonesia Correspondence syahillaefriana05@gmail.com
,
Dwi Sutiningsih Program Study of Magister Epidemiology, Post Graduate School, Universitas Diponegoro, Semarang, Indonesia, Indonesia Correspondence dwisutiningsih@lecturer.undip.ac.id
,
Farid Agushybana Departement of Biostatistic, Faculty of Public Health, Universitas Diponegoro, Semarang, Indonesia, Indonesia Correspondence agushybana@lecturer.undip.ac.id
,
Martini Martini Departement of Epidemiology, Faculty of Public Health, Universitas Diponegoro, Semarang, Indonesia, Indonesia Correspondence martini@live.undip.ac.id
,
Mohammad Zen Rahfiludin Department of Public Health Nutrition, Faculty of Public Health, Universitas Diponegoro, Semarang, Indonesia, Indonesia Correspondence rahfiludinzen@gmail.com
Pages 30-38
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Abstract

Leptospirosis is a priority zoonotic disease in Indonesia and has the potential to cause outbreaks. The mortality rate of leptospirosis cases ranges from 5-20%. Predictors of mortality in leptospirosis include advanced age, oliguria, shortness of breath, icterus, thrombocytopenia, and elevated levels of potassium, creatinine, bilirubin, and urea. The purpose of this study was to analyze mortality predictor factors based on laboratory results in leptospirosis patients in Demak Regency, Indonesia. Data were obtained from 51 leptospirosis patients based on hospital medical record data in Demak Regency for 2018-2023. The study design used was a retrospective cohort. Predictors of mortality were analyzed with Cox regression. The results showed causes of death include: thrombocytopenia <100,000 cells/mm³ (53.33%), creatinine >3 mg/dL (58.33%), and urea >90 mg/dL (61.54%). Laboratory results shown to be associated with mortality have been identified, including platelets <100,000 cells/mm³ (HR: 5.39; CI 95%: 1.23-23.59; p-value: 0.0063), creatinine >3 mg/dL (HR: 4.37; CI 95%: 1.43-13.3; p-value: 0.0040), and urea >90 mg/dL (HR: 7.44; 95% CI: 1.70-32.44; p-value: 0.0008). Research concludes, platelets, creatinine, and urea are predictors of leptospirosis mortality. This study presents significant clinical implications for the management of leptospirosis in improving the treatment of patients. Detection of these predictors will help to quickly identify patient severity, thereby enabling decision making regarding early use of intensive care.

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How to Cite This

Efriana, S., Sutiningsih, D., Agushybana, F., Martini, M., & Zen Rahfiludin , M. (2026). The laboratory examination results: platelet, creatinine, and urea as predictors of mortality in Leptospirosis patients. Jurnal Teknologi Laboratorium, 15(1), 30–38. https://doi.org/10.29238/teknolabjournal.v15i1.474

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