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Immunology

The potency of green grass jelly extract (Premna oblongifolia Merr) as antihyperlipidemia towards aorta histopathology representation of rat (Rattus norvegicus) induced with high fatty diet (HFD)

Eka Nora Vitaloka Aprilia Putri Winthoko Post-Graduates School of Immunology, Universitas Airlangga, Indonesia, Indonesia Correspondence vitalokaaprilia@gmail.com
,
Anna Roosdiana Department of Chemistry, Faculty of Mathematic and Science, Universitas Brawijaya, Indonesia, Indonesia Correspondence arros@ub.ac.id
,
Dyah Ayu Oktaviani A Pratama Department of Veterinery, Faculty of Veteriner, Universitas Brawijaya, Indonesia, Indonesia Correspondence dyahayoe_oap@yahoo.com
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Jusak Nugraha Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, Indonesia, Indonesia Correspondence jusak.nugraha@yahoo.com
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Marijam Purwanta Department of Pharmacy, Faculty of Pharmacy, Universitas Airlangga, Indonesia, Indonesia Correspondence marijampurwanta@yahoo.com
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Muh Husni Rifa’I Department of Veterinery, Faculty of Veteriner, Universitas Brawijaya, Indonesia, Indonesia Correspondence muhrifai@yahoo.com
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Achmad Nur Rendy Department of Veterinery, Faculty of Veteriner, Universitas Brawijaya, Indonesia, Indonesia Correspondence ach_rendy@gmail.com
Pages 97-102
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Abstract

Green grass jelly (Premna oblongifolia merr) is a plant containing fiber and chlorophyll which can lower cholesterol and triglyceride levels. This study have aims to investigate the potency of green grass jelly extract (Premna oblongifolia Merr) to prevent hyperlipidemia. The animal mode used for this study is male Rattus norvegicus, Wistar strain, the age of 8 weeks, and weight of 200 g which is divided into 5 groups of treatment namely group Kn (negative control), Kp (positive control), Kp1, Kp2, and Kp3 induced with HFD and green grass jelly extract at a dose of 5.27 g/ kg BW/ daily, 8.43 g/ kg BW/ daily, 9.37 g/ kg BW/ daily. The data of infiltrating fatty cells and macrophage on aorta histopathology was analyzed by description. This research showed that the treatment of green grass jelly extract (Premna oblongifolia Merr) to animals of hyperlipidemia model reduced infiltration fatty cells and macrophage. The conclusion of this study was the green grass jelly extract was able to prevent an increase of fatty cells and macrophage infiltration of rat (Rattus noervegicus) induced with HFD on dose 9.37 g/ kg/ BW/ daily.

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How to Cite This

Winthoko, E. N. V. A. P., Roosdiana, A., Pratama, D. A. O. A., Nugraha, J., Purwanta, M., Rifa’I, M. H., & Rendy, A. N. (2020). The potency of green grass jelly extract (Premna oblongifolia Merr) as antihyperlipidemia towards aorta histopathology representation of rat (Rattus norvegicus) induced with high fatty diet (HFD). Jurnal Teknologi Laboratorium, 9(1), 97–102. https://doi.org/10.29238/teknolabjournal.v9i1.174

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