Chymase level in dengue virus infection with or without positive Non-Structural 1(NS1)
Thrombocytopenia, leukopenia, and monocytosis are laboratory parameters in the diagnosis of dengue virus infection. In addition to monocyte cells, mast cells also play a role in the innate immune response, where degranulation of mast cells will occur, which will secretion the active vaso mediator, Chymase. Chymase has a role in increasing vascular permeability resulting in plasma leakage in patients with dengue virus infection to determine the number of platelets, leukocytes, monocytes and chymase levels in patients with dengue infection in the acute phase. The platelet count mean in NS1 (+) was 132,140 cells / mm3 and the platelet count in the NS1 group was (-) 176,000 cells / mm3. The mean leukocytes NS1 (+) showed results of 4,350 cells / mm3 and NS1 (-) 5,250 cells / mm3. The mean monocyte NS1 (+) monocyte count was 8.26%, and NS1 (-) group was 8.76%. There were no significant differences in platelet counts, leukocytes and monocytes between NS1 (+) and NS1 (-) (P value> 0.05). The mean Chymase NS1 (+) 23.48, NS1 (-) 23.05 ng / mL and the control group 1.47ng / mL.
There is no Figure or data content available for this article
2. Guzman MG, Gubler DJ, Izquierdo A, Martinez E, Halstead SB. Dengue infection. Nat Publ Gr. 2016;2:1-26. doi:10.1038/nrdp.2016.55
3. Yap SSL, Nguyen-khuong T, Rudd PM, Alonso S. Dengue Virus Glycosylationâ€¯: What Do We Knowâ€¯? 2017;8(July):1-16. doi:10.3389/fmicb.2017.01415
4. Perng GC, Yoksan S, Pattanapanyasat K, Ahmed R, Pulendran B. Dengue Virus Infection Induces Expansion of a CD14+ CD16+ Monocyte Population that Stimulates Plasmablast Differentiation. 2015;16(1):115-127. doi:10.1016/j.chom.2014.06.001.Dengue
5. John ALS. Influence of Mast Cells on Dengue Protective Immunity and Immune Pathology. 2013;9(12):2011-2014. doi:10.1371/journal.ppat.1003783
6. Sala-cunill A. The Mast Cell, Contact , and Coagulation System Connection in Anaphylaxis. 2017;8(July):1-6. doi:10.3389/fimmu.2017.00846
7. Tissera H, Rathore APS, Leong Y, et al. Chymase Level Is a Predictive Biomarker of Dengue Hemorrhagic Fever in Pediatric and Adult Patients. 2018;216(April). doi:10.1093/infdis/jix447
8. Pejler G, Ro E, Waern I, Wernersson S. Review article Mast cell proteasesâ€¯: multifaceted regulators of inflammatory disease. 2018;115(24):4981-4991. doi:10.1182/blood-2010-01-257287.
9. Wernersson S, Pejler G. Mast cell secretory granulesâ€¯: armed for battle. Nat Publ Gr. 2014;(June). doi:10.1038/nri3690
10. Badave GK, Swaroop PS, Rao PN. Original Research Article Importance of NS1 antigen detection and its association with platelet count for early diagnosis of dengue virus infection. 2015;4(3):779-784.
11. Siregar D, Djadja IM, Arminsih R. Analysis of the Risk Factors of Dengue Hemorrhagic Fever ( DHF ) In Rural Populations in Panongan Subdistrict , Tangerang 2016. 2017;2017:119-128. doi:10.18502/kls.v4i1.1373
12. Joshi AA, Gayathri BR, Muneer F. Dynamics of differential count in dengue. 2018;5(1):145-150.
13. Jatmiko SW. Korelasi umur dengan kadar hematokrit, jumlah leukosit, dan trombosit pasien infeksi virus dengue. 2018;10:126.
14. Utari FP, Efrida, Kadri H. Perbandingan Nilai Hematokrit dan Jumlah Trombosit antara Infeksi Dengue Primer dan Dengue Sekunder pada Anak di RSUP Dr. M. Djamil. 2018;7(1):118-123.
15. Tsai J, Chang J, Chang K, et al. Transient Monocytosis Subjugates Low Platelet Count in Adult Dengue Patients. 2017;457785. doi:10.1159/000457785
How to Cite This
Copyright and Permissions
Publishing your paper with Jurnal Teknologi Laboratorium (JTL) means that the author or authors retain the copyright in the paper. JTL granted an exclusive reuse license by the author(s), but the author(s) are able to put the paper onto a website, distribute it to colleagues, give it to students, use it in your thesis etc, even commercially. The author(s) can reuse the figures and tables and other information contained in their paper published by JTL in future papers or work without having to ask anyone for permission, provided that the figures, tables or other information that is included in the new paper or work properly references the published paper as the source of the figures, tables or other information, and the new paper or work is not direct at private monetary gain or commercial advantage.
JTL journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. This journal is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License. This license lets others remix, transform, and build upon the material for any purpose, even commercially.
JTL journal Open Access articles are distributed under this Creative Commons Attribution-ShareAlike 4.0 International License (CC BY-SA). Articles can be read and shared for All purposes under the following conditions:
- BY: You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- SA: If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.